LEUPEPTIN INACTIVATION lgl
نویسنده
چکیده
Leupeptin~ a proteinase inhibitor obtained from culture f i l t rates of Streptomyces sp.~ has been proposed as a valuable agent for the restriction of proteolysis in vivo. We have previously shown tha t mammalian tissues possess an enzymic system that is capable of inactivating leupeptin (Beynon R39 Brown CP & Butler PEr 1981, Acta Biol. Med. Germ. @0, 153%1546). This paper demonstrates the ubiquitous distribution of the inactivating system throughout mammalian tissues and provides evidence for the location of the enzyme(s) in the soluble fraction of the cell.
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